TL;DR: Yes, Copilot can now run on Claude and other models — here's how and when it makes sense Microsoft 365 Copilot is no longer locked to OpenAI — Anthropic's Claude models are now available across Researcher, Copilot Chat, Copilot Studio, Excel and SharePoint Admins opt in (or out) centrally via the Microsoft 365 admin centre — nothing is enabled without your say-so In the UK and EU, Claude access is off by default, so a deliberate decision is required You often don't need a separate Claude licence at all — access can be enabled inside your existing Microsoft 365 environme...